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What is Long-R3-IGF-1?
- Aug 23, 2019-

IGF-I, also known as growth-promoting factor C, belongs to the insulin gene family and is structurally similar to the insulin precursor protein. It has a better growth-promoting effect and promotes the division, migration and differentiation of most cells.

Human long R3 insulin-like growth factor (Long-R3-IGF-I, LR3 IGF-I) is an analog of human IGF-I containing 83 amino acids. Compared to intact human IGF-I, 13 amino acid residues are added at the N-terminus, and it is especially important that the third amino acid residue is replaced by the native Glu to Arg (hence the name R3). Compared with human natural IGF-I, LR3 IGF-I greatly reduced the binding ability to human IGF-I binding protein, and the free concentration was higher, thus significantly increasing the biological activity. In most in vitro assays, LR3 IGF-I is well suited for biological activity at concentrations ranging from 0.2 to 20 ng/ml.

The prokaryotic new process is expressed and prepared, and its activity is superior to that of common commercial products. Purified from recombinant E. coli strain, which carries a plasmid encoding LR3 IGF-I protein.




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