E-mail: [email protected]
Product Categories

Rongxin Bio-Tech Co.,Ltd(H.K.)

FAX: 029-62388781

FEL: +8618220537895

E-mail: [email protected]

Address: Xi'an Jianshe Mansion,China, Shaanxi Sheng, Xian Shi, Yanta Qu, QuJiang ShangQuan, Yanta S Rd

Home > Knowledge > Content
What are the effects of Exemestane?
- Aug 25, 2020 -

Breast cancer cell growth may be estrogen-dependent. Aromatase (exemestane) is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Estrogen deprivation through aromatase inhibition is an effective and selective treatment for some postmenopausal patients with hormone-dependent breast cancer. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It irreversibly binds to the active site causing permanent inhibition necessitating de novo synthesis to restore enzymatic function. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on the adrenal biosynthesis of corticosteroids or aldosterone. This reduction in serum and tumor concentrations of estrogen delays tumor growth and disease progression. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Exemestane(Aromasin) .jpg


If you buy Aromasin (exemestane),Please Contact Us.

Contact information:

Enterprise mailbox:[email protected]

Skype:[email protected]

Whatsapp:+86-1819138529