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What are the effects of Clomifene Citrate?
- Aug 27, 2020-

What are the effects of Clomifene Citrate?

 1. Treatment of anovulatory female infertility, suitable for those with a certain level of estrogen; 2. Treatment of insufficient corpus luteum function; 3. Test of ovarian function; 4. Detection of abnormal function of the male hypothalamic-pituitary-gonadal axis; 5 . Treatment of male infertility due to too few sperm.

Properties: This product is a white piece.

 Resistant hormone drugs. The mechanism of this product to stimulate ovulation is not fully understood. Because this product has a dual effect of weak excitement and strong antagonism on estrogen, ovulation may be stimulated in the hypothalamus. The first antagonism is dominant, and the hypothalamic estrogen receptor is occupied by competition, which interferes with the negative effect of endogenous estrogen. Feedback promotes increased secretion of luteinizing hormone and follicle-stimulating hormone, followed by stimulation of follicle growth. After the follicle matures, the release of estrogen increases, and the release of gonadotropin before ovulation is stimulated by positive feedback to reach the peak value, so ovulation and treatment Male infertility may be related to increased FSH and LH and promotion of sperm production. ™

Pharmacokinetics: After oral administration, it is absorbed through the intestine and enters the hepatic blood circulation. T1/2 is generally 5-7 days. This product is metabolized in the liver. It enters the intestines with bile and is then eliminated from the feces, and part of it is reabsorbed through the hepato-intestinal circulation. Half of it is excreted from the feces within 5 days. It can still be detected in feces within 6 weeks.

Usage and dosage: Orally, 50 mg per day for 5 days. Start taking the medicine from the 5th day of the menstrual cycle. If the patient is amenorrhea, he should start taking progesterone on the 5th day of withdrawal bleeding. Patients who have ovulation after treatment but have not conceived can repeat the original treatment course until conception, or repeat 3-4 courses. If the patient does not ovulate after treatment, the dose can be increased to 100 mg per day for 5 days in the next course of treatment. Individual patients can ovulate only when the dose can reach 150 mg per day.

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