To treat androgen insufficiency, Proviron is usually given in a dose of 1 tablet (25 mg) three times a day at the start of treatment. The drug is then continued at a lower maintenance dose, which usually consists of 1 tablet (25 mg) taken once or twice daily. Similar doses are used to support male fertility and are often used with other fertility medications such as injectable FSH. The usual dose for male athletes is 50mg to 150mg of Proviron per day, or 2 to 6 25mg tablets. The drug is usually taken in cycles of 6-12 weeks, which is usually a sufficient period of time to notice the benefits of the drug.

Many bodybuilders prefer to use Proviron 25mg during the dieting phase or during competition preparations, as low estrogen and high androgen levels are particularly desirable. This is especially useful when drugs such as stanozolol, oxandrolone, or primolone are used alone, which are relatively low in androgen content. Mesterolone can be effectively used to upregulate the ratio of androgens to estrogens, thereby increasing muscle stiffness and density, supporting libido and general well-being, and increasing the tendency to burn body fat. Gynecomastia prevention is also commonly used (at similar doses) when other aromatizing estrogenic steroids are administered, usually in combination with 10-20mg of tamoxifen per day.

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