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- Sep 04, 2018-

Production Introduction


GHRP-2, GHRP-6 and GRF were applied in increasing concentrations to partially purified sheep somatrophs to cause a release of growth hormone in a dependent manner. GHRP-6 was not found to increase the cAMP levels. Mixtures of GRF and GHRP-2 5mg were found to increase growth hormone and cAMP levels, but a combination of GHRP-2 and GHRP-6 did not.

When the cells were pretreated with an adenylyl cyclase inhibitor, they did not see a cAMP increase, though there was a growth hormone increase when GRF or GHRP-2 were applied. This antagonist did not prevent cAMP reactions when a combination of growth hormone and GHRP-6 was applied.

When the antagonist was applied to the growth hormone receptor, the GHRP-2 and GRF combination did not increase the cAMP rates, but prevented any release of growth hormone when GRF, GHRP-2, or GHRP-6 were applied.



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