Tamoxifen Citrate  is a non-steroidal anti-estrogen drug. Its structure is similar to estrogen, and there are two isomers of type Z and type E. The two have different physical and chemical properties and different physiological activities. Type E has weak estrogenic activity, and type Z has anti-estrogen effect. If there is an estrogen receptor (ER) in breast cancer cells, estrogen enters the tumor cells, binds to it, promotes the synthesis of tumor cell DNA and m-RNA, and stimulates tumor cell growth. The Z-isomer of tamoxifen enters the cell and competes with ER to form a receptor complex to prevent the effect of estrogen, thereby inhibiting the proliferation of breast cancer cells.

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