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Semaglutide 5mg*10vials

Semaglutide 5mg*10vials

Name:Semaglutide
Synonym:Rybelsus
Specification:5mg*10vials
CAS:910463-68-2
Appearance:White crystalline powder
Molecular Formula:C187H291N45O59

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Product Details

Semaglutide is a GLP-1 analog, which is 94 % of the sequence homogeneity of human GLP-1. Semaglutide serves as a GLP-1 receptor agonist, which can selectively bind and activate the GLP-1 receptor (target of natural GLP-1).

GLP-1 is a physiological hormone that has multiple effects on glucose that is mediated by GLP-1 receptor.

The main mechanism that leads to the extension of Semaglutide half -life is the binding of albumin, which causes a reduction in kidney clearance and preventing metabolic degradation. In addition, the degradation of Simarugan peptides for DPP-4 enzymes is stable.

Semaglutide reduces blood sugar by stimulating insulin secretion and reducing the mechanism of pancreatic hyperglycemia. Both of them occur in glucose dependence. Therefore, when blood glucose is high, it stimulates insulin secretion and inhibit the secretion of pancreatic hyperglycemia. The reduction of blood glucose also involves a slight delay in stomach emptying after meals.

NameSemaglutide
Other NamesRybelsus
specification:5mg/vial,10vials/kit
CAS910463-68-2
Content99%
AppearanceWhite Freeze-dried powder.
Min order quantity1KIT.
Quality standardEnterprise Standard
Shipping MethodEMS,DHL,UPS,TNT or FEDEX,HKEMS.
PackingAs your require
payment MethodBank Transfer Bitcion
StorageClosed, below 2 ~ 8℃ preservation
CertificationHPLC/MS
GradePharmaceutical Grade
PackageCarton
ManufactureRongXin


Semaglutide dosage and usage:

The starting dose of this product is 0.25 mg, subcutaneous injection, once a week for 4 consecutive weeks; since, the dose increases to 0.5 mg each time; if the blood glucose is not controlled, the 0.5 mg dose will be increased to the extreme after 4 weeks, and the amount will be increased to the extreme each time each time. 1 mg, once a week. It can be administered at any time per week, but the two doses should be more than 2 d. If you miss the service, you should add injection within 5 d; more than 5 days, the next administration will be performed according to the original plan.


semaglutide pharmacokinetics:

Patients with T2D injection of this product in the subcutaneous, abdomen, thighs, or upper arms, the concentration of blood medicine is similar. The biological utilization of this product is 89%, and the median peak time is 24 ~ 36 h. Patient's subcutaneous injection of 0.5 or 1 mg, once a week, 4 to 5 weeks, reached a steady -state concentration, with an average stable -state blood concentration of about 65.0 and 123.0 ng • ml -1, respectively.


The average distribution volume of this product is about 12.5 L, the binding rate of plasma albumin> 99%, the apparent clearance rate is about 0.05 L • H -1, and the half -life is about 1 week. Somalug peptides can be detected. This product's main metabolic pathway is a series of β-oxidation of protease shear peptide chain and fatty acid side chain. This product is mainly excreted through urine and feces. Among them, about 3% are excreted from the urine in the original shape of the drug.

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