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History of Melanotan II
- Dec 21, 2017 -

Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). MCs have been implicated in sexual function in animals.


Melanotan II was first synthesized at the University of Arizona.  Researches there knew that onc of the best defenses against skin cancer was melanin activated in the skin, a tan.  They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure.  The body's naturally occuring hormone MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin).  They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning.  What they found was that while it appeared to work, natural MSH had too short a half life in the body to be practical as a therapeutic drug.  So they decided to find a more potent and stable alternative, one that would be more practical.

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